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Try out PMC Labs and tell us what you think. Learn More. See description Experiment 6 in Supplementary Text : Testing the computational model with additional experimental data.
Altered metabolism in cancer cells is pivotal for tumor growth, most notably by providing energy, reducing equivalents and building blocks while several metabolites exert a aling function promoting tumor growth and progression.
A cancer tissue cannot be simply reduced to a bulk of proliferating cells. Tumors Dating sites weird indeed complex How to start a convo with a girl on a dating website dynamic structures where single cells can heterogeneously perform various biological activities with different metabolic requirements. Because tumors are composed of different types of cells with metabolic activities affected by different spatial and temporal contexts, it is important to address metabolism taking into cellular and biological heterogeneity.
In this review, we describe this heterogeneity also in metabolic fluxes, thus showing the relative contribution of different metabolic activities to tumor progression according to the cellular context.
View PDF Download full issue. Add to Mendeley Share. Under an Elsevier user. Abstract Altered metabolism in cancer cells is pivotal for tumor growth, most notably by providing energy, reducing equivalents and building blocks while several metabolites exert a aling function promoting tumor growth and progression. AMPK adenosine monophosphate kinase.